The men entered a store in the 103rd block of Western Avenue, brandished a knife and demanded the cashier empty the registers. The men fled the scene, westbound on 103rd Street.
One man is described as a black male, 20 to 25 years old, 5-foot-11 and 180 pounds. He had a mustache and was wearing a blue Nike hooded sweatshirt, grey sweatpants and white gym shoes.
The second suspect is described as a black male, 21 to 25 years old, 5-foot-6, and 130 pounds.
Anyone with information is asked to call the Area South Detectives at 312-747-8273.